Purpose: To report outcomes of photodynamic therapy (PDT) and combined therapy of PDT with intravitreal Avastin(IVB) in patients with polypoidal choroidal vasculopathy (PCV).
Methods: Thirty-four eyes of 31 patients with subfoveal PCV were evaluated. Nine eyes were treated with PDT and 25 eyes treated with combined therapy of PDT with IVB. All eyes had a follow-up period of at least 12 months. In this retrospective study the demographic features, best corrected visual acuity (VA), fundus color photo, optical coherence tomography (OCT), fluorescein angiography (FA) and indocyanine green angiography (ICGA) of 34 eyes were evaluated.
Results: Visual acuity improved but did not change significantly in the patients with treated with PDT and combined therapy of PDT with IVB (p=0,149; p=0,087). Although the mean central foveal thickness decreased in both groups, there was no statistical significant difference between groups (p=0.98). The polypoidal lesions regressed in 6 (%66,7) of 9 eyes in the monotherapy of PDT group and 16 (%64) of 25 eyes in the combine therapy group.
Conclusions: PDT and combined therapy of PDT with IVB were maintained successful results in patients with polypoidal choroidal vasculopathy (PCV).
Keywords: Polypoidal choroidal vasculopathy, photodynamic therapy, intravitreal Avastin